Norm over at Troll and Flame asks whether new DMs and new players can handle running or playing in a sandbox style campaign. Having never run a sandbox campaign, I can only speculate how a new DM would fare. Being an ultra-planner, I personally would not feel comfortable DM-ing unless I had done quite a lot of the work ahead of time. This may be due in part to the fact that the only systems I've DMed are D&D 3.5 and Mutants and Masterminds, both of which are on the rules-heavy end of the spectrum.
As a player, I feel that little experience is necessary to enjoy a sandbox campaign. For even the greenest tenderfoot, a short briefing by the DM should suffice. Here's an example: